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In subjects with T2D, the GLP-1 secretion is impaired and its insulinotropic and glucagon suppressive actions are weakened
This cyclization also shields internal peptide bonds from exopeptidase and endopeptidase access, extending the effective half-life in biological matrices and reducing the rate of proteolytic degradation in serum-containing cell culture media
It can have side effects and interfere with other drugs you may be taking
Patients should be advised to maintain adequate hydration, and renal function should be monitored if they become unwell
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Pieber TR, Roitelman J, Lee Y, Luskey KL, Stein DT
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